Prefoldin 5 Is Required for Normal Sensory and Neuronal Development in a Murine Model
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چکیده
منابع مشابه
Prefoldin 6 is required for normal microtubule dynamics and organization in Arabidopsis.
Newly translated tubulin molecules undergo a series of complex interactions with nascent chain-binding chaperones, including prefoldin (PFD) and chaperonin-containing TCP-1 (CCT). By screening for oryzalin hypersensitivity, we identified several mutants of Arabidopsis that have lesions in PFD subunits. The pfd6-1 mutant exhibits a range of microtubule defects, including hypersensitivity to oryz...
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WDR91 is a Rab7 effector required for neuronal development
Early-to-late endosome conversion, which is essential for delivery of endosomal cargoes to lysosomes, requires switching of early endosome-specific Rab5 and PtdIns3P to late endosome-specific Rab7 and PtdIns(3,5)P2 In this study, we identify the WD40-repeat protein WDR91 as a Rab7 effector that couples Rab switching with PtdIns3P down-regulation on endosomes. Loss of WDR91 greatly increases end...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m110.177352